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Crosstalk among ERalpha, ERbeta and GPER in pancreatic beta-cells and its role in K+-channels regulation and apoptosis induced by environmental estrogens


Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación.  01/09/2021- 28/02/2025.

PIs: Angel Nadal and Juan Martínez-Pinna.

Regulation of pancreatic β- and α-cell viability and function by estrogen receptors ERβ and GPER: role in diabetes mellitus therapy


Programa de Excelencia PROMETEO, Generalitat Valenciana. 01/01/2020 -31/12/2023

PI: Angel Nadal

Generation Of NoveL, Integrated and Internationally Harmonised Approaches for Testing Metabolism Disrupting Chemicals (GOLIATH).



European Commission H2020. 01/01/2019-31/12/2024.

PI: Angel Nadal

Actions of simoultaneous exposure to endocrine disruptors and high fat diet on pancreatic beta-cell and risk of type-2 diabetes mellitus

Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación. 01/01/2017-31/12/2020.

PI: Angel Nadal

Effects of maternal estrogenic environment on pancreatic beta cell mass and function in offspring: implications in the etiology of type-2 diabetes

Ministerio de Economía y Competitividad. 01/01/2015- 31/12/2017.

PI: Angel Nadal

Role of estrogen receptors in the regulation of pancreatic beta- and alpha-cell mass during pregnancy

Programa de Excelencia PROMETEO, Generalitat Valenciana. 01/01/2015-31/12/2018.

PI: Angel Nadal

Bisphenol-A effects on glucose homeostasis, islet function and insulin signaling in mice

Ministerio de Ciencia e Innovación. 01/01/2012-30/06/2015.

PI: Angel Nadal

Characterization of the rapid insulinotropic effect of specific estrogen receptor beta agonists: implications for the treatment of diabetes

Programa de Excelencia PROMETEO, Generalitat Valenciana. 01/01/2011-31/12/2014.

PI: Angel Nadal