[et_pb_section fb_built=\u00bb1″ fullwidth=\u00bbon\u00bb _builder_version=\u00bb4.16″ custom_margin=\u00bb-130px||-130px||true|false\u00bb custom_padding=\u00bb26px||26px||true|false\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_fullwidth_header title=\u00bbISLET CELL SIGNALING LAB\u00bb subhead=\u00bbPrevenir la diabetes cuidando el medioambiente\u00bb header_fullscreen=\u00bbon\u00bb _builder_version=\u00bb4.17.4″ title_font=\u00bb|600|||||||\u00bb title_text_color=\u00bb #ab1a2d\u00bb title_font_size=\u00bb20px\u00bb content_font=\u00bb||||||||\u00bb content_text_color=\u00bb#000000″ content_font_size=\u00bb20px\u00bb content_line_height=\u00bb1.8em\u00bb subhead_font=\u00bb|700|||||||\u00bb subhead_text_color=\u00bb #ab1a2d\u00bb subhead_font_size=\u00bb53px\u00bb subhead_letter_spacing=\u00bb2px\u00bb subhead_line_height=\u00bb1.2em\u00bb background_enable_color=\u00bboff\u00bb use_background_color_gradient=\u00bbon\u00bb background_color_gradient_type=\u00bbcircular\u00bb background_color_gradient_direction_radial=\u00bbleft\u00bb background_color_gradient_stops=\u00bb#FFFFFF 36%|rgba(19,37,94,0) 100%\u00bb background_color_gradient_overlays_image=\u00bbon\u00bb background_color_gradient_start=\u00bb#FFFFFF\u00bb background_color_gradient_start_position=\u00bb36%\u00bb background_color_gradient_end=\u00bbrgba(19,37,94,0)\u00bb background_image=\u00bbhttps:\/\/isletcellsignal.umh.es\/files\/2022\/06\/header-scaled.jpg\u00bb custom_button_one=\u00bbon\u00bb button_one_text_color=\u00bb#FFFFFF\u00bb button_one_bg_color=\u00bb#ab1a2d\u00bb button_one_border_color=\u00bb #ab1a2d\u00bb button_one_border_radius=\u00bb25px\u00bb button_one_font=\u00bb||||||||\u00bb button_one_use_icon=\u00bboff\u00bb button_one_custom_padding=\u00bb|35px||35px|false|true\u00bb background_layout=\u00bblight\u00bb subhead_font_size_tablet=\u00bb45px\u00bb subhead_font_size_phone=\u00bb38px\u00bb subhead_font_size_last_edited=\u00bbon|phone\u00bb button_one_border_color_last_edited=\u00bboff|desktop\u00bb global_colors_info=\u00bb{}\u00bb button_one_border_color__hover_enabled=\u00bbon|hover\u00bb button_one_border_color__hover=\u00bb #ab1a2d\u00bb button_one_bg_color__hover_enabled=\u00bboff|hover\u00bb button_one_bg_color__hover=\u00bb#8c0000″ button_one_bg_enable_color__hover=\u00bbon\u00bb][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\u00bb1″ _builder_version=\u00bb4.16″ custom_padding=\u00bb||0px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row _builder_version=\u00bb4.16″ global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.17.4″ text_font=\u00bb|700|||||||\u00bb text_font_size=\u00bb19px\u00bb text_line_height=\u00bb1.8em\u00bb header_2_font=\u00bb|600|||||||\u00bb header_2_text_color=\u00bb#8c0000″ header_2_font_size=\u00bb30px\u00bb header_2_line_height=\u00bb1.2em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n
[\/et_pb_text][et_pb_button button_text=\u00bbLEER M\u00c1S\u00bb button_alignment=\u00bbcenter\u00bb module_class=\u00bbrv_button\u00bb _builder_version=\u00bb4.17.4″ custom_button=\u00bbon\u00bb button_text_color=\u00bb#ffffff\u00bb button_bg_color=\u00bb#ab1a2d\u00bb button_border_color=\u00bb #ab1a2d\u00bb button_border_radius=\u00bb13px\u00bb background_layout=\u00bbdark\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.16″ global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.16″ global_colors_info=\u00bb{}\u00bb][et_pb_text module_id=\u00bbreveal\u00bb _builder_version=\u00bb4.17.4″ text_font=\u00bb|300|||||||\u00bb text_font_size=\u00bb19px\u00bb text_line_height=\u00bb1.8em\u00bb header_2_font=\u00bb|600|||||||\u00bb header_2_text_color=\u00bb#8c0000″ header_2_font_size=\u00bb30px\u00bb header_2_line_height=\u00bb1.2em\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n
La diabetes mellitus se produce cuando la glucosa en sangre es demasiado elevada. La glucosa aumenta despu\u00e9s de las comidas y proporciona energ\u00eda a nuestras c\u00e9lulas tras ser absorbida con la ayuda de la insulina, una hormona producida y secretada por las c\u00e9lulas \u03b2 del islote de Langerhans situado en el p\u00e1ncreas. Cuando las c\u00e9lulas \u03b2 no producen suficiente insulina, o la se\u00f1alizaci\u00f3n de la insulina est\u00e1 disminuida, se elevan los niveles de glucosa en sangre por encima de los valores normales.Para saber m\u00e1s sobre la diabetes mellitus visite https:\/\/www.idf.org\/aboutdiabetes\/what-is-diabetes.html<\/a><\/span><\/span><\/p>\n El mundo se enfrenta a una epidemia de diabetes; 422 millones de personas en todo el mundo padecen la enfermedad y una persona muere cada 7 segundos a causa de la diabetes y sus complicaciones. Para disminuir estas cifras, es imperativo investigar qu\u00e9 factores causan la diabetes y entender c\u00f3mo lo hacen. Esto nos permitir\u00eda intervenir y prevenir su aparici\u00f3n.<\/p>\n La probabilidad de convertirse en diab\u00e9tico incluye la predisposici\u00f3n gen\u00e9tica individual y los factores ambientales que desencadenan la aparici\u00f3n de la enfermedad. No podemos cambiar nuestros genes pero nuestro ambiente s\u00ed. Cambi\u00e1ndolo podemos prevenir o al menos, retrasar la diabetes.<\/p>\n El ambiente a nivel celular abarca m\u00faltiples factores, que van desde la composici\u00f3n nutricional hasta la presencia de contaminantes qu\u00edmicos. Un grupo de estos contaminantes son especialmente importantes en la etiolog\u00eda de la diabetes. Son los conocidos como disruptores endocrinos (DEs). Para saber m\u00e1s sobre los DEs, visite https:\/\/www.endocrine.org\/topics\/edc<\/span><\/a>.<\/p>\n Las DEs son sustancias qu\u00edmicas que imitan, bloquean o interfieren con la acci\u00f3n de las hormonas del sistema endocrino de nuestro organismo.. A diario, la poblaci\u00f3n est\u00e1 expuesta a dosis baja de DEs . Algunos DEs aumentan la probabilidad de padecer diabetes de forma indirecta porque causan obesidad, pero los DEs tambi\u00e9n da\u00f1an las c\u00e9lulas \u03b2 y causan resistencia a la insulina en diferentes tejidos. As\u00ed pues, muchos DEs son diabet\u00f3genas por derecho propio. Para saber m\u00e1s sobre los DEs y la diabetes mellitus, visite https:\/\/www.diabetesandenvironment.org\/<\/a><\/span><\/span><\/p>\n En nuestro grupo, nos centramos en c\u00f3mo los DEs modifican la funci\u00f3n y la supervivencia de las c\u00e9lulas de los islotes para entender c\u00f3mo los DEs influyen en la homeostasis de la glucosa. [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb0px||0px|||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row column_structure=\u00bb1_4,1_4,1_4,1_4″ make_equal=\u00bbon\u00bb _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb max_width=\u00bb1307px\u00bb custom_css_main_element=\u00bbalign-items: center;\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_4″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_image src=\u00bbhttps:\/\/isletcellsignal.umh.es\/files\/2024\/05\/logo-dem.png\u00bb alt=\u00bbLogo Ciberdem\u00bb title_text=\u00bblogo-dem\u00bb url=\u00bbhttps:\/\/www.ciberdem.org\/\u00bb url_new_window=\u00bbon\u00bb _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb 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[et_pb_section fb_built=\"1\" fullwidth=\"on\" _builder_version=\"4.16\" custom_margin=\"-130px||-130px||true|false\" custom_padding=\"26px||26px||true|false\" global_colors_info=\"{}\"][et_pb_fullwidth_header title=\"ISLET CELL SIGNALING LAB\" subhead=\"Preventing Diabetes by Caring for the Environment\" header_fullscreen=\"on\" button_one_text=\"LATEST NEWS\" _builder_version=\"4.16\" title_font=\"|600|||||||\" title_text_color=\" #ab1a2d\" title_font_size=\"20px\" content_font=\"||||||||\" content_text_color=\"#000000\" content_font_size=\"20px\" content_line_height=\"1.8em\" subhead_font=\"|700|||||||\" subhead_text_color=\" #ab1a2d\" subhead_font_size=\"53px\" subhead_letter_spacing=\"2px\" subhead_line_height=\"1.2em\" background_enable_color=\"off\" use_background_color_gradient=\"on\" background_color_gradient_type=\"circular\" background_color_gradient_direction_radial=\"left\" background_color_gradient_stops=\"#FFFFFF 36%|rgba(19,37,94,0) 100%\" background_color_gradient_overlays_image=\"on\" background_color_gradient_start=\"#FFFFFF\" background_color_gradient_start_position=\"36%\" background_color_gradient_end=\"rgba(19,37,94,0)\" background_image=\"https:\/\/isletcellsignal.umh.es\/files\/2022\/06\/header-scaled.jpg\" custom_button_one=\"on\" button_one_text_color=\"#FFFFFF\" button_one_bg_color=\"#ab1a2d\" button_one_border_color=\" #ab1a2d\" button_one_border_radius=\"25px\" button_one_font=\"||||||||\" button_one_use_icon=\"off\" button_one_custom_padding=\"|35px||35px|false|true\" background_layout=\"light\" button_one_border_color_last_edited=\"off|desktop\" global_colors_info=\"{}\" button_one_border_color__hover_enabled=\"on|hover\" button_one_border_color__hover=\" #ab1a2d\" button_one_bg_color__hover_enabled=\"off|hover\" button_one_bg_color__hover=\"#8c0000\" button_one_bg_enable_color__hover=\"on\"][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" custom_padding=\"||0px|||\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.16\" text_font=\"|700|||||||\" text_font_size=\"19px\" text_line_height=\"1.8em\" header_2_font=\"|600|||||||\" header_2_text_color=\"#8c0000\" header_2_font_size=\"30px\" header_2_line_height=\"1.2em\" global_colors_info=\"{}\"]<\/p> [\/et_pb_text][et_pb_button button_text=\"READ MORE\" button_alignment=\"center\" module_class=\"rv_button\" _builder_version=\"4.16\" custom_button=\"on\" button_text_color=\"#ffffff\" button_bg_color=\"#ab1a2d\" button_border_color=\" #ab1a2d\" button_border_radius=\"13px\" button_icon=\"\"||divi||400\" background_layout=\"dark\" global_colors_info=\"{}\"][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_text module_id=\"reveal\" _builder_version=\"4.17.4\" text_font=\"|300|||||||\" text_font_size=\"19px\" text_line_height=\"1.8em\" header_2_font=\"|600|||||||\" header_2_text_color=\"#8c0000\" header_2_font_size=\"30px\" header_2_line_height=\"1.2em\" global_colors_info=\"{}\"]<\/p> Diabetes mellitus occurs when blood glucose is too high. Glucose rises after meals and provides energy to our cells after being absorbed with the help of insulin, a hormone produced and secreted by the \u03b2-cells of the islet of Langerhans located in the pancreas. When \u03b2-cells do not produce enough insulin, or insulin signaling is diminished, excessively high blood glucose levels result. To know more about diabetes mellitus visit <\/span><\/p> https:\/\/www.idf.org\/aboutdiabetes\/what-is-diabetes.html<\/span><\/a><\/span><\/p> The world is facing a diabetes epidemic. 422 million people worldwide suffer from the disease and one person dies every 7 seconds from diabetes and its complications. To decrease these numbers, it is imperative to investigate what factors cause diabetes and to understand how they do so. This would allow us to intervene and prevent its onset.<\/span><\/p> The probability of becoming diabetic includes individual genetic predisposition and environmental factors that trigger the onset of the disease. Genes cannot be modified, but the environment can, and by changing the environment we can prevent or delay diabetes.<\/span><\/p> We can define the environment as everything but the genome. It encompasses multiple factors, from nutrition to chemical pollutants. There is a group of chemical pollutants that are especially important in the etiology of diabetes, the so-called endocrine disruptors or endocrine disrupting chemicals (EDCs). To know more about EDCs visit https:\/\/www.endocrine.org\/topics\/edc<\/span><\/a>.<\/span><\/p>
Trasladamos este conocimiento en acciones para disminuir la prevalencia de la diabetes y los trastornos metab\u00f3licos relacionados.<\/p>\nWe work to understand how chemical pollutants influence glucose homeostasis. Our ultimate goal is to translate this knowledge into actions to decrease the prevalence of diabetes and related metabolic disorders.<\/span><\/h2>