[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.16″ custom_margin=”-130px||-130px||true|false” custom_padding=”26px||26px||true|false” global_colors_info=”{}”][et_pb_fullwidth_header title=”ISLET CELL SIGNALING LAB” subhead=”Previndre la diabetis cuidant el medi ambient” header_fullscreen=”on” _builder_version=”4.17.4″ title_font=”|600|||||||” title_text_color=” #ab1a2d” title_font_size=”20px” content_font=”||||||||” content_text_color=”#000000″ content_font_size=”20px” content_line_height=”1.8em” subhead_font=”|700|||||||” subhead_text_color=” #ab1a2d” subhead_font_size=”53px” subhead_letter_spacing=”2px” subhead_line_height=”1.2em” background_enable_color=”off” use_background_color_gradient=”on” background_color_gradient_type=”circular” background_color_gradient_direction_radial=”left” background_color_gradient_stops=”#FFFFFF 36%|rgba(19,37,94,0) 100%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#FFFFFF” background_color_gradient_start_position=”36%” background_color_gradient_end=”rgba(19,37,94,0)” background_image=”https:\/\/isletcellsignal.umh.es\/files\/2022\/06\/header-scaled.jpg” custom_button_one=”on” button_one_text_color=”#FFFFFF” button_one_bg_color=”#ab1a2d” button_one_border_color=” #ab1a2d” button_one_border_radius=”25px” button_one_font=”||||||||” button_one_use_icon=”off” button_one_custom_padding=”|35px||35px|false|true” background_layout=”light” subhead_font_size_tablet=”45px” subhead_font_size_phone=”38px” subhead_font_size_last_edited=”on|phone” button_one_border_color_last_edited=”off|desktop” global_colors_info=”{}” button_one_border_color__hover_enabled=”on|hover” button_one_border_color__hover=” #ab1a2d” button_one_bg_color__hover_enabled=”off|hover” button_one_bg_color__hover=”#8c0000″ button_one_bg_enable_color__hover=”on”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ text_font=”|700|||||||” text_font_size=”19px” text_line_height=”1.8em” header_2_font=”|600|||||||” header_2_text_color=”#8c0000″ header_2_font_size=”30px” header_2_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][et_pb_button button_text=”M\u00c9S INFORMACI\u00d3” button_alignment=”center” module_class=”rv_button” _builder_version=”4.17.4″ custom_button=”on” button_text_color=”#ffffff” button_bg_color=”#ab1a2d” button_border_color=” #ab1a2d” button_border_radius=”13px” background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text module_id=”reveal” _builder_version=”4.17.4″ text_font=”||||||||” text_font_size=”19px” text_line_height=”1.8em” header_2_font=”|600|||||||” header_2_text_color=”#8c0000″ header_2_font_size=”30px” header_2_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n
La diabetis mellitus es produeix quan la glucosa en sang \u00e9s massa elevada. La glucosa augmenta despr\u00e9s de la ingesta i proporciona energia a les nostres c\u00e8l\u00b7lules despr\u00e9s de ser absorbida amb l’ajuda de la insulina, una hormona produ\u00efda i secretada per les c\u00e8l\u00b7lules-\u03b2 del’illot de Langerhans situat en el p\u00e0ncrees. Quan les c\u00e8l\u00b7lules-\u03b2 no produeixen suficient insulina, o la senyalitzaci\u00f3 de la insulina est\u00e0 disminu\u00efda, es produeixen nivells de glucosa en sang excessivament alts. Per a saber m\u00e9s sobre la diabetis mellitus visite El m\u00f3n s’enfronta a una epid\u00e8mia de diabetis. 422 milions de persones a tot el m\u00f3n pateixen la malaltia i una persona mor cada 7 segons a causa de la diabetis i les seues complicacions. Per a disminuir aquestes xifres, \u00e9s imperatiu investigar quins factors causen la diabetis i entendre com ho fan. Aix\u00f2 ens permetria intervindre i previndre la seua aparici\u00f3. La probabilitat de convertir-se en diab\u00e8tic inclou la predisposici\u00f3 gen\u00e8tica individual i els factors ambientals que desencadenen l’aparici\u00f3 de la malaltia. Els gens no poden modificar-se, per\u00f2 l’entorn s\u00ed, i canviant l’entorn podem previndre o retardar la diabetis. Podem definir l’entorn com tot el que no \u00e9s el genoma. Implica m\u00faltiples factors, des de la nutrici\u00f3 fins als contaminants qu\u00edmics. Hi ha un grup de contaminants qu\u00edmics que s\u00f3n especialment importants en l’etiologia de la diabetis, els anomenats disruptors endocrins (DEs). Per a saber m\u00e9s sobre els DEs, visite Les DEs s\u00f3n subst\u00e0ncies qu\u00edmiques que imiten, bloquegen o interfereixen amb les hormones del sistema endocr\u00ed de l\u2019organisme. Estem exposats a dosis baixes de DEs di\u00e0riament. Alguns DEs augmenten la probabilitat de patir diabetis de manera indirecta perqu\u00e8 causen obesitat, per\u00f2 els DEs tamb\u00e9 afecten negativament les c\u00e8l\u00b7lules-\u03b2 i causen resist\u00e8ncia a la insulina en diferents teixits. Aix\u00ed doncs, moltes DEs s\u00f3n diabet\u00f2gens per dret propi. Per a saber m\u00e9s sobre els DEs i la diabetis mellitus, visite En el nostre grup, ens centrem en com els DEs modifiquen la funci\u00f3 i la superviv\u00e8ncia de les c\u00e8l\u00b7lules dels illots per a entendre com els DEs influeixen en l’home\u00f2stasi de la glucosa. Tradu\u00efm aquest coneixement en accions per a disminuir la prevalen\u00e7a de la diabetis i els trastorns metab\u00f2lics relacionats.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.17.4″ _module_preset=”default” custom_padding=”0px||0px|||” global_colors_info=”{}”][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ make_equal=”on” _builder_version=”4.17.4″ _module_preset=”default” max_width=”1307px” custom_css_main_element=”align-items: center;” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/isletcellsignal.umh.es\/files\/2024\/05\/logo-dem.png” alt=”Logo Ciberdem” title_text=”logo-dem” url=”https:\/\/www.ciberdem.org\/” url_new_window=”on” _builder_version=”4.17.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ 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alt=”Logo MICINN” title_text=”Logo MICINN” url=”https:\/\/www.ciencia.gob.es\/” url_new_window=”on” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" P\u00e1gina de presentaci\u00f3n de la unidad organizativa<\/p>\n","protected":false},"author":3158,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":" [et_pb_section fb_built=\"1\" fullwidth=\"on\" _builder_version=\"4.16\" custom_margin=\"-130px||-130px||true|false\" custom_padding=\"26px||26px||true|false\" global_colors_info=\"{}\"][et_pb_fullwidth_header title=\"ISLET CELL SIGNALING LAB\" subhead=\"Preventing Diabetes by Caring for the Environment\" header_fullscreen=\"on\" button_one_text=\"LATEST NEWS\" _builder_version=\"4.16\" title_font=\"|600|||||||\" title_text_color=\" #ab1a2d\" title_font_size=\"20px\" content_font=\"||||||||\" content_text_color=\"#000000\" content_font_size=\"20px\" content_line_height=\"1.8em\" subhead_font=\"|700|||||||\" subhead_text_color=\" #ab1a2d\" subhead_font_size=\"53px\" subhead_letter_spacing=\"2px\" subhead_line_height=\"1.2em\" background_enable_color=\"off\" use_background_color_gradient=\"on\" background_color_gradient_type=\"circular\" background_color_gradient_direction_radial=\"left\" background_color_gradient_stops=\"#FFFFFF 36%|rgba(19,37,94,0) 100%\" background_color_gradient_overlays_image=\"on\" background_color_gradient_start=\"#FFFFFF\" background_color_gradient_start_position=\"36%\" background_color_gradient_end=\"rgba(19,37,94,0)\" background_image=\"https:\/\/isletcellsignal.umh.es\/files\/2022\/06\/header-scaled.jpg\" custom_button_one=\"on\" button_one_text_color=\"#FFFFFF\" button_one_bg_color=\"#ab1a2d\" button_one_border_color=\" #ab1a2d\" button_one_border_radius=\"25px\" button_one_font=\"||||||||\" button_one_use_icon=\"off\" button_one_custom_padding=\"|35px||35px|false|true\" background_layout=\"light\" button_one_border_color_last_edited=\"off|desktop\" global_colors_info=\"{}\" button_one_border_color__hover_enabled=\"on|hover\" button_one_border_color__hover=\" #ab1a2d\" button_one_bg_color__hover_enabled=\"off|hover\" button_one_bg_color__hover=\"#8c0000\" button_one_bg_enable_color__hover=\"on\"][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" custom_padding=\"||0px|||\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.16\" text_font=\"|700|||||||\" text_font_size=\"19px\" text_line_height=\"1.8em\" header_2_font=\"|600|||||||\" header_2_text_color=\"#8c0000\" header_2_font_size=\"30px\" header_2_line_height=\"1.2em\" global_colors_info=\"{}\"]<\/p> [\/et_pb_text][et_pb_button button_text=\"READ MORE\" button_alignment=\"center\" module_class=\"rv_button\" _builder_version=\"4.16\" custom_button=\"on\" button_text_color=\"#ffffff\" button_bg_color=\"#ab1a2d\" button_border_color=\" #ab1a2d\" button_border_radius=\"13px\" button_icon=\"\"||divi||400\" background_layout=\"dark\" global_colors_info=\"{}\"][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_text module_id=\"reveal\" _builder_version=\"4.17.4\" text_font=\"|300|||||||\" text_font_size=\"19px\" text_line_height=\"1.8em\" header_2_font=\"|600|||||||\" header_2_text_color=\"#8c0000\" header_2_font_size=\"30px\" header_2_line_height=\"1.2em\" global_colors_info=\"{}\"]<\/p> Diabetes mellitus occurs when blood glucose is too high. Glucose rises after meals and provides energy to our cells after being absorbed with the help of insulin, a hormone produced and secreted by the \u03b2-cells of the islet of Langerhans located in the pancreas. When \u03b2-cells do not produce enough insulin, or insulin signaling is diminished, excessively high blood glucose levels result. To know more about diabetes mellitus visit <\/span><\/p> https:\/\/www.idf.org\/aboutdiabetes\/what-is-diabetes.html<\/span><\/a><\/span><\/p> The world is facing a diabetes epidemic. 422 million people worldwide suffer from the disease and one person dies every 7 seconds from diabetes and its complications. To decrease these numbers, it is imperative to investigate what factors cause diabetes and to understand how they do so. This would allow us to intervene and prevent its onset.<\/span><\/p> The probability of becoming diabetic includes individual genetic predisposition and environmental factors that trigger the onset of the disease. Genes cannot be modified, but the environment can, and by changing the environment we can prevent or delay diabetes.<\/span><\/p> We can define the environment as everything but the genome. It encompasses multiple factors, from nutrition to chemical pollutants. There is a group of chemical pollutants that are especially important in the etiology of diabetes, the so-called endocrine disruptors or endocrine disrupting chemicals (EDCs). To know more about EDCs visit https:\/\/www.endocrine.org\/topics\/edc<\/span><\/a>.<\/span><\/p>
https:\/\/www.idf.org\/aboutdiabetes\/what-is-diabetes.html<\/a><\/p>\n
https:\/\/www.endocrine.org\/topics\/edc.<\/a><\/p>\n
https:\/\/www.diabetesandenvironment.org\/ <\/a><\/p>\nWe work to understand how chemical pollutants influence glucose homeostasis. Our ultimate goal is to translate this knowledge into actions to decrease the prevalence of diabetes and related metabolic disorders.<\/span><\/h2>