{"id":1483,"date":"2022-10-06T21:00:19","date_gmt":"2022-10-06T21:00:19","guid":{"rendered":"https:\/\/isletcellsignal.umh.es\/?page_id=1483"},"modified":"2024-11-25T08:00:30","modified_gmt":"2024-11-25T08:00:30","slug":"projecte-prometeo","status":"publish","type":"page","link":"https:\/\/isletcellsignal.umh.es\/ca\/projecte-prometeo\/","title":{"rendered":"Projecte Prometeo"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.17.4″ custom_margin=”-130px||-130px||false|false” custom_padding=”26px||26px||false|false” global_colors_info=”{}”][et_pb_fullwidth_header title=”DIABETES RESEARCH UNIT” subhead=”Projecte Prometeu” header_fullscreen=”on” _builder_version=”4.17.4″ title_font=”|600|||||||” title_text_color=” #ab1a2d” title_font_size=”20px” content_font=”||||||||” content_text_color=”#000000″ content_font_size=”20px” content_line_height=”1.8em” subhead_font=”|700|||||||” subhead_text_color=” #ab1a2d” subhead_font_size=”53px” subhead_letter_spacing=”2px” subhead_line_height=”1.2em” background_enable_color=”off” use_background_color_gradient=”on” background_color_gradient_type=”circular” background_color_gradient_direction_radial=”left” background_color_gradient_stops=”#FFFFFF 36%|rgba(19,37,94,0) 100%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#FFFFFF” background_color_gradient_start_position=”36%” background_color_gradient_end=”rgba(19,37,94,0)” background_image=”https:\/\/isletcellsignal.umh.es\/files\/2022\/09\/prometeo-umh.png” custom_button_one=”on” button_one_text_color=”#FFFFFF” button_one_bg_color=”#ab1a2d” button_one_border_color=” #ab1a2d” button_one_border_radius=”25px” button_one_font=”||||||||” button_one_use_icon=”off” button_one_custom_padding=”|35px||35px|false|true” background_layout=”light” custom_margin=”||-65px|||” button_one_border_color_last_edited=”off|desktop” global_colors_info=”{}” button_one_border_color__hover_enabled=”on|hover” button_one_border_color__hover=” #ab1a2d” button_one_bg_color__hover_enabled=”off|hover” button_one_bg_color__hover=”#8c0000″ button_one_bg_enable_color__hover=”on”]\"\"
\n[\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.17.4″ _module_preset=”default” custom_padding=”0px||0px|||” global_colors_info=”{}”][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ text_font=”|700|||||||” text_text_color=”#ab1a2d” text_font_size=”19px” text_line_height=”1.8em” header_2_font=”|600|||||||” header_2_text_color=”#8c0000″ header_2_font_size=”30px” header_2_line_height=”1.2em” custom_margin=”-2px|||||” global_colors_info=”{}”]<\/p>\n

OBJECTIUS<\/span><\/strong><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_5,3_5,1_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_text_color=”#ab1a2d” text_font_size=”100px” header_font=”|700|||||||” header_font_size=”100px” header_line_height=”1.2em” header_2_text_color=”#ab1a2d” header_2_font_size=”100px” header_2_line_height=”1.2em” custom_margin=”|||32px|false|false” border_width_right=”3px” border_color_right=”#ab1a2d” global_colors_info=”{}”]<\/p>\n

1<\/strong><\/h2>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”16px” custom_padding=”14px||||false|false” global_colors_info=”{}”]<\/p>\n

Estudiar el paper de l’activaci\u00f3 dels receptors d’estr\u00f2gens ER\u03b2 i GPER en la viabilitat de la c\u00e8l\u00b7lula-\u03b2 en pres\u00e8ncia i abs\u00e8ncia d’est\u00edmuls apopt\u00f2tics.<\/strong><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_5,3_5,1_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_text_color=”#ab1a2d” text_font_size=”100px” header_font=”|700|||||||” header_font_size=”100px” header_line_height=”1.2em” header_2_text_color=”#ab1a2d” header_2_font_size=”100px” header_2_line_height=”1.2em” custom_margin=”|||32px|false|false” border_width_right=”3px” border_color_right=”#ab1a2d” global_colors_info=”{}”]<\/p>\n

2<\/strong><\/h2>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”16px” width=”99.8%” custom_padding=”25px||||false|false” global_colors_info=”{}”]<\/p>\n

Analitzar l’efecte de la disminuci\u00f3 de l’expressi\u00f3 dels receptors d’estr\u00f2gens ER\u03b2 i GPER<\/strong>, utilitzant RNA d’interfer\u00e8ncia, en la viabilitat cel\u00b7lular.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_5,3_5,1_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_text_color=”#ab1a2d” text_font_size=”100px” header_font=”|700|||||||” header_font_size=”100px” header_line_height=”1.2em” header_2_text_color=”#ab1a2d” header_2_font_size=”100px” header_2_line_height=”1.2em” custom_margin=”|||32px|false|false” border_width_right=”3px” border_color_right=”#ab1a2d” global_colors_info=”{}”]<\/p>\n

3<\/strong><\/h2>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”16px” custom_padding=”25px||||false|false” global_colors_info=”{}”]<\/p>\n

Caracteritzaci\u00f3 del paper de ER\u03b2 i GPER en la secreci\u00f3 de glucag\u00f3<\/strong>, i en la viabilitat cel\u00b7lular de la c\u00e8l\u00b7lula-\u03b1.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_image src=”https:\/\/isletcellsignal.umh.es\/files\/2022\/06\/icono-1.png” align=”center” _builder_version=”4.17.4″ global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.17.4″ text_font=”||||||||” text_text_color=”#000000″ text_font_size=”19px” text_line_height=”1.8em” header_2_font=”|600|||||||” header_2_text_color=”#8c0000″ header_2_font_size=”30px” header_2_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n

Regulaci\u00f3 de la viabilitat i la funci\u00f3 de les c\u00e8l\u00b7lules \u03b2 i \u03b1 pancre\u00e0tiques pels receptors d’estr\u00f2gens ER\u03b2 i GPER: paper en la ter\u00e0pia de la diabetis mellitus<\/strong><\/p>\n

El 17\u03b2-estradiol (E2) \u00e9s una hormona sexual produ\u00efda per la c\u00e8l\u00b7lula de les granuloses en l’ovari, que est\u00e0 tradicionalment implicada en la diferenciaci\u00f3 sexual, la pubertat i la reproducci\u00f3. En les dues \u00faltimes d\u00e8cades l’impacte de l’E2 ha transcendit a moltes altres funcions fisiol\u00f2giques, entre elles, l’home\u00f2stasi de la glucosa, incloent els seus efectes en les c\u00e8l\u00b7lules \u03b2 i \u03b1 del p\u00e0ncrees endocr\u00ed. L’E2 regula el contingut d’insulina i la seua secreci\u00f3 en resposta a la glucosa, i produeix l’efecte contrari en el cas de la c\u00e8l\u00b7lula-\u03b1 i la secreci\u00f3 de glucag\u00f3. Tamb\u00e9 protegeix la c\u00e8l\u00b7lula-\u03b2 de la mort cel\u00b7lular en resposta a est\u00edmuls apopt\u00f2tics i no es sap si fa el mateix en la c\u00e8l\u00b7lula-\u03b1. El paper del receptor d’estr\u00f2gens ER\u03b1 en la funci\u00f3 i la superviv\u00e8ncia de la c\u00e8l\u00b7lula-\u03b2 est\u00e0 relativament ben estudiat. No ocorre igual amb els altres dos receptors d’estr\u00f2gens, ER\u03b2 i GPER. La dissecci\u00f3 dels mecanismes d’acci\u00f3 de l’E2 a trav\u00e9s dels receptors d’estr\u00f2gens ER\u03b2 i GPER en el p\u00e0ncrees endocr\u00ed que proposem en aquest projecte, ens ajudaren a con\u00e8ixer millor les difer\u00e8ncies de sexe en l’home\u00f2stasi de la glucosa. Aquest coneixement ajudar\u00e0 a millorar el tractament de la diabetis mellitus tipus 2, els efectes secundaris de la hormonoter\u00e0pia per a determinats tipus de c\u00e0ncers dependents d\u2019hormones i a comprendre la fisiologia transg\u00e8nere.<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.17.4″ text_font=”|700|||||||” text_text_color=”#ab1a2d” text_font_size=”19px” text_line_height=”1.8em” header_2_font=”|600|||||||” header_2_text_color=”#8c0000″ header_2_font_size=”30px” header_2_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n

PUBLICACIONS<\/span><\/strong><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.16″ max_width=”100%” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”rgba(255,255,255,0.39)” custom_padding=”30px|30px|30px|30px” box_shadow_style=”preset1″ global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Mart\u00ednez-Pinna J, Sempere-Navarro R, Medina-Gali RM, Fuentes E, Quesada I, Sargis RM, Trasande L, Nadal A. (2023).” url_new_window=”on” content_max_width=”100%” _builder_version=”4.17.4″ header_font=”PT Sans|700|||||||” header_text_color=”#000000″ header_line_height=”25px” body_font=”PT Sans||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.8em” text_orientation=”center” background_layout=”dark” custom_margin=”|||” custom_padding=”|||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%” animation=”off” link_option_url=”https:\/\/doi.org\/10.1016\/j.chemosphere.2020.129051″ link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Endocrine disruptors in plastics alter \u03b2-cell physiology and increase the risk of diabetes mellitus.<\/span><\/p>\n

American Journal of Physiology- Endocrinology and Metabolism 324(6):E488-E505. <\/b><\/p>\n

doi: 10.1152\/ajpendo.00068.2023.<\/b><\/p>\n

<\/strong><\/span><\/strong><\/p>\n

<\/strong><\/span><\/strong><\/p>\n

[\/et_pb_blurb][et_pb_button button_url=”https:\/\/journals.physiology.org\/doi\/full\/10.1152\/ajpendo.00068.2023″ url_new_window=”on” button_text=”m\u00e9s informaci\u00f3” button_alignment=”center” _builder_version=”4.17.4″ custom_button=”on” button_text_size=”22px” button_text_color=”#ab1a2d” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”0px” button_font=”PT Sans|700||on|||||” button_on_hover=”off” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”rgba(255,255,255,0.39)” custom_padding=”30px|30px|30px|30px” box_shadow_style=”preset1″ global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Dos Santos RS, Babiloni-Chust I, Marroqui L, Nadal A. (2023)” content_max_width=”100%” _builder_version=”4.17.4″ header_font=”PT Sans|700|||||||” header_text_color=”#000000″ header_line_height=”25px” body_font=”PT Sans||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.8em” text_orientation=”center” custom_margin=”|||” custom_padding=”|||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%” animation=”off” global_colors_info=”{}”]<\/p>\n

Screening of Metabolism-Disrupting Chemicals on Pancreatic \u03b1-Cells Using In Vitro Methods.<\/span><\/p>\n

International Journal of Molecular Sciences. 24(1):231. <\/b><\/p>\n

doi: 10.3390\/ijms24010231.<\/b><\/p>\n

[\/et_pb_blurb][et_pb_button button_url=”https:\/\/www.mdpi.com\/1422-0067\/24\/1\/231″ url_new_window=”on” button_text=”m\u00e9s informaci\u00f3” button_alignment=”center” _builder_version=”4.17.4″ custom_button=”on” button_text_size=”22px” button_text_color=”#ab1a2d” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”0px” button_font=”PT Sans|700||on|||||” button_on_hover=”off” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”rgba(255,255,255,0.39)” custom_padding=”30px|30px|30px|30px” box_shadow_style=”preset1″ global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Perez-Serna AA, Dos Santos RS, Ripoll C, Nadal A, Eizirik DL, Marroqui L. (2023)” content_max_width=”100%” _builder_version=”4.17.4″ header_font=”PT Sans|700|||||||” header_text_color=”#000000″ header_line_height=”25px” body_font=”PT Sans||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.8em” text_orientation=”center” background_layout=”dark” custom_margin=”|||” custom_padding=”|||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%” animation=”off” global_colors_info=”{}”]<\/p>\n

BCL-XL Overexpression Protects Pancreatic \u03b2-Cells against Cytokine- and Palmitate-Induced Apoptosis.<\/span><\/p>\n

International Journal of Molecular Sciences. 2023 Mar 16;24(6):5657. <\/b><\/p>\n

doi: 10.3390\/ijms24065657.<\/b><\/p>\n

<\/strong><\/p>\n

[\/et_pb_blurb][et_pb_button button_url=”https:\/\/www.mdpi.com\/1422-0067\/24\/6\/5657″ url_new_window=”on” button_text=”m\u00e9s informaci\u00f3” button_alignment=”center” _builder_version=”4.17.4″ custom_button=”on” button_text_size=”22px” button_text_color=”#ab1a2d” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”0px” button_font=”PT Sans|700||on|||||” button_on_hover=”off” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.16″ max_width=”100%” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”rgba(255,255,255,0.39)” custom_padding=”30px|30px|30px|30px” box_shadow_style=”preset1″ global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Babiloni-Chust I, Dos Santos RS, Medina-Gali RM, Perez-Serna AA, Encinar JA, Martinez-Pinna J, Gustafsson JA, Marroqui L, Nadal A. (2022)” content_max_width=”100%” _builder_version=”4.17.4″ header_font=”PT Sans|700|||||||” header_text_color=”#000000″ header_line_height=”25px” body_font=”PT Sans||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.8em” text_orientation=”center” custom_margin=”|||” custom_padding=”|||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%” animation=”off” global_colors_info=”{}”]<\/p>\n

G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ER\u03b1 and ER\u03b2 in pancreatic beta cells.<\/p>\n

Environment International 164:107250<\/span><\/strong><\/p>\n

doi:\u00a010.1016\/j.envint.2022.107250<\/strong><\/span><\/strong>\u00a0<\/p>\n

[\/et_pb_blurb][et_pb_button button_url=”https:\/\/doi.org\/10.1016\/j.envint.2022.107250″ url_new_window=”on” button_text=”m\u00e9s informaci\u00f3” button_alignment=”center” _builder_version=”4.17.4″ custom_button=”on” button_text_size=”22px” button_text_color=”#ab1a2d” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”0px” button_font=”PT Sans|700||on|||||” button_on_hover=”off” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”rgba(255,255,255,0.39)” custom_padding=”30px|30px|30px|30px” box_shadow_style=”preset1″ global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Dos Santos RS, Medina-Gali RM, Babiloni-Chust I, Marroqui L, Nadal A. (2022)” content_max_width=”100%” _builder_version=”4.17.4″ header_font=”PT Sans|700|||||||” header_text_color=”#000000″ header_line_height=”25px” body_font=”PT Sans||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.8em” text_orientation=”center” background_layout=”dark” custom_margin=”|||” custom_padding=”|||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%” animation=”off” global_colors_info=”{}”]<\/p>\n

In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic \u03b2-Cell Model.<\/p>\n

Int J Mol Sci. 23(9):5040<\/strong><\/p>\n

doi:10.3390\/ijms2309504<\/strong><\/strong>\u00a0<\/p>\n

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[\/et_pb_blurb][et_pb_button button_url=”https:\/\/doi.org\/10.3390\/ijms23095040″ url_new_window=”on” button_text=”m\u00e9s informaci\u00f3” button_alignment=”center” _builder_version=”4.17.4″ custom_button=”on” button_text_size=”22px” button_text_color=”#ab1a2d” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”0px” button_font=”PT Sans|700||on|||||” button_on_hover=”off” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”rgba(255,255,255,0.39)” custom_padding=”30px|30px|30px|30px” box_shadow_style=”preset1″ global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Tudur\u00ed E, Soriano S, Almagro L, Garc\u00eda-Heredia A, Rafacho A, Alonso-Magdalena P, Nadal \u00c1, Quesada I. (2022)” content_max_width=”100%” _builder_version=”4.17.4″ header_font=”PT Sans|700|||||||” header_text_color=”#000000″ header_line_height=”25px” body_font=”PT Sans||||||||” body_text_color=”rgba(255,255,255,0.7)” body_font_size=”16px” body_line_height=”1.8em” text_orientation=”center” background_layout=”dark” custom_margin=”|||” custom_padding=”|||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%” animation=”off” global_colors_info=”{}”]<\/p>\n

The effects of aging on male mouse pancreatic \u03b2-cell function involve multiple events in the regulation of secretion: influence of insulin sensitivity.<\/span><\/p>\n

J Gerontol A Biol Sci Med Sci. 25: glab276 <\/span><\/strong><\/p>\n

doi: 10.1093\/gerona\/glab276<\/span><\/strong>\u00a0<\/p>\n

[\/et_pb_blurb][et_pb_button button_url=”https:\/\/doi.org\/10.1093\/gerona\/glab276″ url_new_window=”on” button_text=”m\u00e9s informaci\u00f3” button_alignment=”center” _builder_version=”4.17.4″ custom_button=”on” button_text_size=”22px” button_text_color=”#ab1a2d” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”0px” button_font=”PT Sans|700||on|||||” button_on_hover=”off” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.17.4″ max_width=”100%” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”rgba(255,255,255,0.39)” custom_padding=”30px|30px|30px|30px” box_shadow_style=”preset1″ global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Tudur\u00ed E, Soriano S, Almagro L, Montanya E, Alonso-Magdalena P, Nadal \u00c1, Quesada I. (2022)” content_max_width=”100%” _builder_version=”4.17.4″ header_font=”PT Sans|700|||||||” header_text_color=”#000000″ header_line_height=”25px” body_font=”PT Sans||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.8em” text_orientation=”center” custom_margin=”|||” custom_padding=”|||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%” animation=”off” global_colors_info=”{}”]<\/p>\n

The pancreatic \u03b2-cell in ageing: Implications in age-related diabetes.<\/span><\/p>\n

Ageing Res Rev. 80:101674.<\/span><\/strong><\/p>\n

doi:\u00a010.1016\/j.arr.2022.101674<\/strong><\/span><\/strong><\/p>\n

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[\/et_pb_blurb][et_pb_button button_url=”https:\/\/doi.org\/10.1016\/j.arr.2022.101674″ url_new_window=”on” button_text=”m\u00e9s informaci\u00f3” button_alignment=”center” _builder_version=”4.17.4″ custom_button=”on” button_text_size=”22px” button_text_color=”#ab1a2d” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”0px” button_font=”PT Sans|700||on|||||” button_on_hover=”off” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”rgba(255,255,255,0.39)” custom_padding=”30px|30px|30px|30px” box_shadow_style=”preset1″ global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Marroqui L, Martinez-Pinna J, Castellano-Mu\u00f1oz M, Dos Santos RS, Medina-Gali RM, Soriano S, Quesada I, Gustafsson JA, Encinar JA, Nadal A. (2021)” url_new_window=”on” content_max_width=”100%” _builder_version=”4.17.4″ header_font=”PT Sans|700|||||||” header_text_color=”#000000″ header_line_height=”25px” body_font=”PT Sans||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.8em” text_orientation=”center” background_layout=”dark” custom_margin=”|||” custom_padding=”|||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%” animation=”off” link_option_url=”https:\/\/doi.org\/10.1016\/j.chemosphere.2020.129051″ link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

Bisphenol-S and Bisphenol-F alter mouse pancreatic \u03b2-cell ion channel expression and activity and insulin release through an estrogen receptor ER\u03b2 mediated pathway<\/p>\n

doi: 10.1016\/j.chemosphere.2020.129051<\/strong><\/span><\/strong>\u00a0<\/p>\n

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[\/et_pb_blurb][et_pb_button url_new_window=”on” button_text=”m\u00e9s informaci\u00f3” button_alignment=”center” _builder_version=”4.17.4″ custom_button=”on” button_text_size=”22px” button_text_color=”#ab1a2d” button_border_width=”0px” button_border_radius=”0px” button_letter_spacing=”0px” button_font=”PT Sans|700||on|||||” button_on_hover=”off” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.17.4″ background_color=”rgba(255,255,255,0.39)” custom_padding=”30px|30px|30px|30px” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ text_font=”|700|||||||” text_text_color=”#ab1a2d” text_font_size=”19px” text_line_height=”1.8em” header_2_font=”|600|||||||” header_2_text_color=”#8c0000″ header_2_font_size=”30px” header_2_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n

MEMBRES<\/span><\/strong><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/isletcellsignal.umh.es\/files\/2024\/11\/AN5.png” title_text=”AN5″ _builder_version=”4.17.4″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][et_pb_text module_class=”rv_button3″ _builder_version=”4.17.4″ _module_preset=”default” header_5_font=”||||||||” header_5_font_size=”18px” global_colors_info=”{}”]<\/p>\n

Investigador Principal<\/h5>\n

[\/et_pb_text][et_pb_button button_text=”ANGEL NADAL” button_alignment=”center” module_class=”rv_button3″ _builder_version=”4.17.4″ custom_button=”on” button_text_color=”#ffffff” button_bg_color=”#ab1a2d” button_border_color=” #ab1a2d” button_border_radius=”13px” button_icon=”"||divi||400″ background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][et_pb_text module_id=”reveal3″ _builder_version=”4.17.4″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”16px” global_colors_info=”{}”]<\/p>\n

\u00c1ngel Nadal \u00e9s catedr\u00e0tic de Fisiologia i subdirector del IDiBE en la Universitat Miguel Hern\u00e1ndez d’Elx i cap de grup i membre del Comit\u00e9 de Direcci\u00f3 del CIBERDEM. Les seues investigacions han demostrat la relaci\u00f3 entre l’exposici\u00f3 al Bisfenol-A i les alteracions del metabolisme de la glucosa, incloent l’estudi dels esdeveniments moleculars inicials. Aquestos resultats han sigut fonamentals per a establir la relaci\u00f3 entre l’exposici\u00f3 als disruptors endocrins i la diabetis mellitus. El seu inter\u00e9s continua en l’estudi de com el medi ambient afecta a la divisi\u00f3, mort i funci\u00f3 de les c\u00e8l\u00b7lules -\u03b2 i la seua implicaci\u00f3 en el desenvolupament de la diabetis. Ha sigut reconegut amb el premi de la Societat Espanyola de Diabetis al millor investigador jove (2004) i el premi Alberto Sols a la investigaci\u00f3 b\u00e0sica en diabetis (2017). Participa habitualment en la millora de la translaci\u00f3 de la ci\u00e8ncia dels disruptors endocrins a la regulaci\u00f3.
https:\/\/orcid.org\/0000-0003-4178-2152<\/span><\/a><\/span><\/p>\n

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[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member image_url=”https:\/\/isletcellsignal.umh.es\/files\/2022\/11\/paloma-alonso-magdalena-1.png” _builder_version=”4.17.4″ _module_preset=”default” header_font=”|700|||||||” header_font_size=”19px” body_font=”|600|||||||” body_text_align=”center” body_text_color=”#000000″ body_font_size=”16px” position_text_color=”rgba(0,0,0,0.88)” text_orientation=”center” global_colors_info=”{}”][\/et_pb_team_member][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” header_5_text_color=”#000000″ header_5_font_size=”18px” global_colors_info=”{}”]<\/p>\n

Investigadora<\/h5>\n

[\/et_pb_text][et_pb_button button_text=”PALOMA ALONSO-MAGADALENA” button_alignment=”center” module_class=”rv_button14″ _builder_version=”4.17.4″ custom_button=”on” button_text_size=”19px” button_text_color=”#ffffff” button_bg_color=”#ab1a2d” button_border_color=” #ab1a2d” button_border_radius=”13px” button_icon=”"||divi||400″ background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][et_pb_text module_id=”reveal14″ _builder_version=”4.17.4″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”16px” global_colors_info=”{}”]<\/p>\n

Paloma Alonso-Magdalena va estudiar Biologia a la Universitat d’Oviedo. Va obtenir el seu doctorat a la Universitat Miguel Hern\u00e1ndez i va realitzar una estada postdoctoral al Departament de Nutrici\u00f3 del Karolinska Institutet d’Estocolm (Su\u00e8cia) on va estudiar la fisiologia del receptor d&#39;estr\u00f2gens ER\u03b2. Tamb\u00e9 va ser investigadora visitant al Center for Nuclear Receptors and Cell Signaling de Houston (EUA). Actualment \u00e9s professora de Nutrici\u00f3 i Bromatologia de la Universitat Miguel Hern\u00e1ndez d’Elx i investigadora principal de l’IDiBE. La seva investigaci\u00f3 se centra a entendre el paper que tenen els disruptius endocrins (EDC) en l&#39;etiologia de la diabetis, l’obesitat i els trastorns metab\u00f2lics relacionats. El seu treball ha estat decisiu per vincular l’exposici\u00f3 a certs disruptors endocrins generalitzats com el bisfenol-A amb l’etiopatologia de la diabetis tipus 2. A m\u00e9s, est\u00e0 interessada en la fisiologia i les adaptacions metab\u00f2liques de les c\u00e8l\u00b7lules alfa i beta pancre\u00e0tiques durant l&#39;embar\u00e0s. Est\u00e0 especialment centrada en la comprensi\u00f3 de les bases moleculars de la diabetis mellitus gestacional i la identificaci\u00f3 de vies de senyalitzaci\u00f3 alterades que condueixen al desenvolupament d’aquesta malaltia. Va ser guardonada amb el premi de la Societat Espanyola de Diabetis a la millor investigadora jove (2018)
https:\/\/orcid.org\/0000-0003-1065-5388<\/a><\/span><\/p>\n

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Investigadora<\/h5>\n

[\/et_pb_text][et_pb_button button_text=”ESTHER FUENTES” button_alignment=”center” module_class=”rv_button4″ _builder_version=”4.17.4″ custom_button=”on” button_text_size=”19px” button_text_color=”#ffffff” button_bg_color=”#ab1a2d” button_border_width=”17px” button_border_color=” #ab1a2d” button_border_radius=”12px” button_icon=”"||divi||400″ background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][et_pb_text module_id=”reveal4″ _builder_version=”4.17.4″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”16px” global_colors_info=”{}”]<\/p>\n

Esther Fuentes va estudiar Bioqu\u00edmica en la Universitat de Val\u00e8ncia (Espanya) i es va doctorar en el King’s College de Londres (Regne Unit). \u00c9s professora de Nutrici\u00f3 i Bromatologia en la Universitat Miguel Hern\u00e1ndez d’Elx. Compagina el seu inter\u00e9s investigador en el paper dels disruptors endocrins en els trastorns metab\u00f2lics amb el seu c\u00e0rrec de Vicerectora adjunta de Cultura.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Cristina Ripoll” position=”Investigadora” image_url=”https:\/\/isletcellsignal.umh.es\/files\/2022\/09\/avatar.png” _builder_version=”4.17.4″ _module_preset=”default” header_font=”|700|||||||” header_font_size=”19px” body_font=”|600|||||||” body_text_align=”center” body_text_color=”#000000″ body_font_size=”16px” position_text_color=”rgba(0,0,0,0.88)” text_orientation=”center” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member image_url=”https:\/\/isletcellsignal.umh.es\/files\/2022\/11\/ivan-quesada-moll.png” _builder_version=”4.17.4″ _module_preset=”default” header_font=”|700|||||||” header_font_size=”19px” body_font=”|600|||||||” body_text_align=”center” body_text_color=”#000000″ body_font_size=”16px” position_text_color=”rgba(0,0,0,0.88)” text_orientation=”center” global_colors_info=”{}”][\/et_pb_team_member][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” header_5_text_color=”#000000″ header_5_font_size=”18px” global_colors_info=”{}”]<\/p>\n

Investigador<\/h5>\n

[\/et_pb_text][et_pb_button button_text=”IV\u00c1N QUESADA” button_alignment=”center” module_class=”rv_button13″ _builder_version=”4.17.4″ custom_button=”on” button_text_size=”19px” button_text_color=”#ffffff” button_bg_color=”#ab1a2d” button_border_width=”17px” button_border_color=” #ab1a2d” button_border_radius=”12px” button_icon=”"||divi||400″ background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][et_pb_text module_id=”reveal13″ _builder_version=”4.17.4″ _module_preset=”default” text_text_color=”#000000″ text_font_size=”16px” global_colors_info=”{}”]<\/p>\n

Ivan Quesada \u00e9s catedr\u00e0tic de Nutrici\u00f3 de la Universitat Miguel Hern\u00e1ndez d’Elx. Va obtenir el seu doctorat a la Universitat Miguel Hern\u00e1ndez (2000) i va realitzar una estada postdoctoral a la Universitat de Washington a Seattle (2001-2003). El Dr. Quesada tamb\u00e9 va ser convidat com a Visiting Assistant Professor per ensenyar a la Universitat de Washington (2004). Els seus estudis s’han centrat en entendre les alteracions, adaptacions i\/o fallades de les c\u00e8l\u00b7lules alfa i beta pancre\u00e0tiques en condicions fisiol\u00f2giques com l’embar\u00e0s i l’envelliment, aix\u00ed com en condicions patol\u00f2giques com l’obesitat i la diabetis. La seva investigaci\u00f3 en els darrers anys ha contribu\u00eft principalment a una millor comprensi\u00f3 de la biologia de les c\u00e8l\u00b7lules alfa pancre\u00e0tiques en salut i malaltia, i la seva contribuci\u00f3 a la diabetis. Va ser guardonat per la Societat Espanyola de Diabetis al millor investigador jove (2008).
https:\/\/orcid.org\/0000-0002-9808-514X<\/a><\/span><\/p>\n

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P\u00e1gina de presentaci\u00f3n de la unidad organizativa<\/p>\n","protected":false},"author":3158,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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\"\"<\/p>

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OBJETIVOS<\/span><\/strong><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_5,3_5,1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#ab1a2d\" text_font_size=\"100px\" header_font=\"|700|||||||\" header_font_size=\"100px\" header_line_height=\"1.2em\" header_2_text_color=\"#ab1a2d\" header_2_font_size=\"100px\" header_2_line_height=\"1.2em\" custom_margin=\"|||32px|false|false\" border_width_right=\"3px\" border_color_right=\"#ab1a2d\" global_colors_info=\"{}\"]<\/p>

1<\/strong><\/h2>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"3_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#000000\" text_font_size=\"16px\" custom_padding=\"14px||||false|false\" global_colors_info=\"{}\"]<\/p>

Estudiar el papel de la activaci\u00f3n de los receptores de estr\u00f3genos en ER\u03b2 y GPER\u00a0en la viabilidad de la c\u00e9lula-\u03b2 en presencia y ausencia de est\u00edmulos apopt\u00f3ticos.<\/strong><\/p><\/div><\/div>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_5,3_5,1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#ab1a2d\" text_font_size=\"100px\" header_font=\"|700|||||||\" header_font_size=\"100px\" header_line_height=\"1.2em\" header_2_text_color=\"#ab1a2d\" header_2_font_size=\"100px\" header_2_line_height=\"1.2em\" custom_margin=\"|||32px|false|false\" border_width_right=\"3px\" border_color_right=\"#ab1a2d\" global_colors_info=\"{}\"]<\/p>

2<\/strong><\/h2>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"3_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#000000\" text_font_size=\"16px\" width=\"99.8%\" custom_padding=\"25px||||false|false\" global_colors_info=\"{}\"]<\/p>

Analizar el efecto de la disminuci\u00f3n de la expresi\u00f3n de los receptores de estr\u00f3genos ER\u03b2 y GPER<\/strong>, usando RNA de interferencia, en la viabilidad celular.<\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_5,3_5,1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#ab1a2d\" text_font_size=\"100px\" header_font=\"|700|||||||\" header_font_size=\"100px\" header_line_height=\"1.2em\" header_2_text_color=\"#ab1a2d\" header_2_font_size=\"100px\" header_2_line_height=\"1.2em\" custom_margin=\"|||32px|false|false\" border_width_right=\"3px\" border_color_right=\"#ab1a2d\" global_colors_info=\"{}\"]<\/p>

3<\/strong><\/h2>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"3_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#000000\" text_font_size=\"16px\" custom_padding=\"25px||||false|false\" global_colors_info=\"{}\"]<\/p>

Caracterizaci\u00f3n del papel de ER\u03b2 y GPER en la secreci\u00f3n de glucag\u00f3n,<\/strong>\u00a0y en la viabilidad celular de la c\u00e9lula-\u03b1.<\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_image src=\"https:\/\/isletcellsignal.umh.es\/files\/2022\/06\/icono-1.png\" align=\"center\" _builder_version=\"4.17.4\" global_colors_info=\"{}\"][\/et_pb_image][et_pb_text _builder_version=\"4.17.4\" text_font=\"|300|||||||\" text_text_color=\"#000000\" text_font_size=\"19px\" text_line_height=\"1.8em\" header_2_font=\"|600|||||||\" header_2_text_color=\"#8c0000\" header_2_font_size=\"30px\" header_2_line_height=\"1.2em\" global_colors_info=\"{}\"]<\/p>

Regulaci\u00f3n de la viabilidad y la funci\u00f3n de las c\u00e9lulas \u03b2 y \u03b1 pancre\u00e1ticas por los receptores de estr\u00f3genos ER\u03b2 y GPER: papel en la terapia de la diabetes mellitus<\/strong><\/p>

El 17\u03b2-estradiol (E2) es una hormona sexual producida por la c\u00e9lula de las granulosas en el ovario, que est\u00e1 tradicionalmente implicada en la diferenciaci\u00f3n sexual, la pubertad y la reproducci\u00f3n. En las dos \u00faltimas d\u00e9cadas el impacto del E2 ha trascendido a muchas otras funciones fisiol\u00f3gicas, entre ellas, la homeostasis de la glucosa, incluyendo sus efectos en las c\u00e9lulas \u03b2 y \u03b1 del p\u00e1ncreas endocrino. El E2regula el contenido de insulina y su secreci\u00f3n en respuesta a la glucosa, y produce elefecto contrario en el caso de la c\u00e9lula-\u03b1 y la secreci\u00f3n de glucag\u00f3n. Tambi\u00e9n protege a la c\u00e9lula-\u03b2 de la muerte celular en respuesta a est\u00edmulos apopt\u00f3ticos y no se sabe si hace lo mismo en la c\u00e9lula-\u03b1. El papel del receptor de estr\u00f3genos ER\u03b1 en la funci\u00f3n y la supervivencia de la c\u00e9lula-\u03b2 est\u00e1 relativamente bien estudiado. No ocurre igual con los otros dos receptores de estr\u00f3genos, ER\u03b2 y GPER. La disecci\u00f3n de los mecanismos de acci\u00f3n del E2 a trav\u00e9s de los receptores de estr\u00f3genos ER\u03b2 y GPER en el p\u00e1ncreas endocrino que proponemos en este proyecto, nos ayudaran a conocer mejor las diferencias de sexo en la homeostasis de la glucosa. Este conocimiento ayudar\u00e1 a mejorar el tratamiento de la diabetes mellitus tipo 2, los efectos secundarios de la hormonoterapia para determinados tipos de canceres hormonodependientes y a comprender la fisiolog\u00eda transg\u00e9nero.<\/p>

[\/et_pb_text][et_pb_text _builder_version=\"4.17.4\" text_font=\"|700|||||||\" text_text_color=\"#ab1a2d\" text_font_size=\"19px\" text_line_height=\"1.8em\" header_2_font=\"|600|||||||\" header_2_text_color=\"#8c0000\" header_2_font_size=\"30px\" header_2_line_height=\"1.2em\" global_colors_info=\"{}\"]<\/p>

PUBLICACIONES<\/span><\/strong><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" gutter_width=\"2\" make_equal=\"on\" _builder_version=\"4.16\" max_width=\"100%\" global_colors_info=\"{}\"][et_pb_column type=\"1_3\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.39)\" custom_padding=\"30px|30px|30px|30px\" box_shadow_style=\"preset1\" global_colors_info=\"{}\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Marroqui L, Martinez-Pinna J, Castellano-Mu\u00f1oz M, Dos Santos RS, Medina-Gali RM, Soriano S, Quesada I, Gustafsson JA, Encinar JA, Nadal A. (2021)\" url_new_window=\"on\" content_max_width=\"100%\" _builder_version=\"4.17.4\" header_font=\"PT Sans|700|||||||\" header_text_color=\"#000000\" header_line_height=\"25px\" body_font=\"PT Sans||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.8em\" text_orientation=\"center\" background_layout=\"dark\" custom_margin=\"|||\" custom_padding=\"|||\" animation_style=\"slide\" animation_direction=\"bottom\" animation_intensity_slide=\"10%\" animation=\"off\" link_option_url=\"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.129051\" link_option_url_new_window=\"on\" global_colors_info=\"{}\"]Bisphenol-S and Bisphenol-F alter mouse pancreatic \u03b2-cell ion channel expression and activity and insulin release through an estrogen receptor ER\u03b2 mediated pathway


doi: 10.1016\/j.chemosphere.2020.129051<\/strong><\/span><\/strong><\/p>


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G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ER\u03b1 and ER\u03b2 in pancreatic beta cells.<\/p>

Environment International 164:107250<\/span><\/strong><\/p>

doi:\u00a010.1016\/j.envint.2022.107250<\/strong><\/span><\/strong><\/p>

\u00a0<\/p>

\u00a0<\/p>

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In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic \u03b2-Cell Model.<\/p>

Int J Mol Sci. 23(9):5040<\/strong><\/p>

doi:10.3390\/ijms23095040<\/strong><\/p>

\u00a0<\/p>

\u00a0<\/p>

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J Gerontol A Biol Sci Med Sci. 25: glab276 <\/span><\/strong><\/p>

doi: 10.1093\/gerona\/glab276<\/span><\/strong><\/p>

\u00a0<\/p>

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The pancreatic \u03b2-cell in ageing: Implications in age-related diabetes.<\/span>

<\/p>

Ageing Res Rev. 80:101674.<\/span><\/strong><\/p>

doi:\u00a010.1016\/j.arr.2022.101674<\/strong><\/span><\/strong><\/p>

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MIEMBROS<\/span><\/strong><\/h2>

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